Pathological Hallmarks of AD

Senile Plaques (SPs) Core of amyloid b peptide (Ab), a proteolytic fragment of amyloid precursor protein (APP) Surrounded by reactive astrocytes, microglia, and containing a host of associated proteins

Neurofibrillary Tangles (NFTs) Composed of paired helical filaments (PHFs) PHFs are composed of a hyperphosphorylated form of the microtubule associated protein tau

Affinity Labeling Technologies,

Inc

. 1999

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